PAPER I JUN 2007
Q. Describe the classifications of lymphomas.
Mature B-cell neoplasms
· Chronic lymphocytic leukemia/small lymphocytic lymphoma
· B-cell prolymphocytic leukemia
· Splenic marginal zone lymphoma
o Hairy cell leukemia
o Splenic lymphoma/leukemia, unclassifiable
o Splenic diffuse red pulp small B-cell lymphoma*
· Hairy cell leukemia-variant*
· Lymphoplasmacytic lymphoma
o Waldenström macroglobulinemia
· Heavy chain diseases
o Alpha heavy chain disease
o Gamma heavy chain disease
o Mu heavy chain disease Plasma cell myeloma
· Solitary plasmacytoma of bone
· Extraosseous plasmacytoma
· Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
· Nodal marginal zone B-cell lymphoma (MZL)
o Pediatric type nodal MZL
· Follicular lymphoma
o Pediatric type follicular lymphoma
· Primary cutaneous follicle center lymphoma
· Mantle cell lymphoma
· Diffuse large B-cell lymphoma (DLBCL), not otherwise specified
o T cell/histiocyte rich large B-cell lymphoma
o DLBCL associated with chronic inflammation
o Epstein-Barr virus (EBV)+ DLBCL of the elderly
· Lymphomatoid granulomatosis
· Primary mediastinal (thymic) large B-cell lymphoma
· Intravascular large B-cell lymphoma
· Primary cutaneous DLBCL, leg type
· ALK+ large B-cell lymphoma
· Plasmablastic lymphoma
· Primary effusion lymphoma
· Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
· Burkitt lymphoma
· B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
· B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
· Hodgkin Lymphoma
· Nodular lymphocyte-predominant Hodgkin lymphoma
· Classical Hodgkin lymphoma
o Nodular sclerosis classical Hodgkin lymphoma
o Lymphocyte-rich classical Hodgkin lymphoma
o Mixed cellularity classical Hodgkin lymphoma
o Lymphocyte-depleted classical Hodgkin lymphoma
Mature T-cell neoplasms
· T-cell prolymphocytic leukemia
· T-cell large granular lymphocytic leukemia
· Chronic lymphoproliferative disorder of NK-cells*
· Aggressive NK cell leukemia Systemic EBV+ T-cell lymphoproliferative disease of childhood (associated with chronic active EBV infection)
· Hydroa vacciniforme-like lymphoma
· Adult T-cell leukemia/lymphoma
· Extranodal NK/T cell lymphoma, nasal type
· Enteropathy-associated T-cell lymphoma
· Hepatosplenic T-cell lymphoma
· Subcutaneous panniculitis-like T-cell lymphoma
· Mycosis fungoides Sézary syndrome
· Primary cutaneous CD30+ T-cell lymphoproliferative disorder
o Lymphomatoid papulosis
o Primary cutaneous anaplastic large-cell lymphoma
· Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma*
· Primary cutaneous gamma-delta T-cell lymphoma
· Primary cutaneous small/medium CD4+ T-cell lymphoma*
· Peripheral T-cell lymphoma, not otherwise specified
· Angioimmunoblastic T-cell lymphoma
· Anaplastic large cell lymphoma (ALCL),
· ALK+ Anaplastic large cell lymphoma (ALCL), ALK–*
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