June 2017
https://sites.google.com/site/surgerypaper/2017/hipec
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https://sites.google.com/site/surgerypaper/2017/hipec
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Hyperthermic
intraperitoneal chemotherapy (HIPEC) is a highly concentrated, heated
chemotherapy treatment delivered directly to the abdomen during surgery.
Unlike systemic chemotherapy
delivery, which circulates throughout the body via the bloodstream, HIPEC
delivers chemotherapy directly to cancer cells in the abdomen. This allows for
higher doses of chemotherapy treatment. Heating the solution may also improve
the absorption of chemotherapy drugs by tumors and destroy microscopic cancer
cells that remain in the abdomen after surgery.
Before patients receive HIPEC
treatment, doctors perform cytoreductive surgery—a procedure to debulk, or
reduce, the size of a cancerous tumor—within the abdomen. When as many tumors
as possible have been removed, a heated, sterilized chemotherapy solution is
delivered to the abdomen to penetrate and destroy remaining cancer cells. The solution is 41 to 42 degrees
Celsius, about the temperature of a warm bath. It’s circulated throughout the
abdomen for approximately 90 minutes. The solution is then drained from the
abdomen, and the incision is closed.
HIPEC is a treatment option for people who have
advanced surface spread of cancer within the abdomen, but no cancer outside the
abdomen.
HIPEC:
·
Allows for high doses of chemotherapy
·
Enhances and concentrates chemotherapy within
the abdomen
·
Reduces the rest of the body’s exposure to the
chemotherapy
·
Improves chemotherapy absorption and
susceptibility of cancer cells
·
Reduces some chemotherapy side effects
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